Key result
CD209 knockout mice showed decreased numbers of Ly6Chigh monocytes in infarcted hearts compared to wild-type mice (491 vs. 915 monocytes/mg infarct tissue, p<0.05).
Why the study?
Little was known about whether bone marrow supplies qualitatively different monocytes during the course of myocardial infarction beyond a quantitative increase in production.
Population
Non-infarcted mice, infarcted mice, CD209+/+ and CD209-/- mice, and THP-1 cells
Comparison
Infarcted vs non-infarcted mice, and CD209 overexpression or knockout vs controls
Design
Preclinical animal and in vitro mechanistic study
Authors
Loading...
May refine post-MI anti-inflammatory strategies; extends quantitative BM models with first qualitative monocyte data.
Absolute Event Rate: 491% vs 915%
p-value: p=<0.05
The bone marrow alters the monocyte repertoire post-MI, with CD209 playing a key role in monocyte recruitment to the ischemic heart, representing a potential therapeutic target for post-MI remodeling.
Moggio et al. (2023) studied Myocardial infarction. CD209 knockout vs. Wild type (CD209+/+) was evaluated on Ly6Chigh monocytes in infarcted hearts (cells/mg infarct tissue) (p=<0.05). CD209 knockout mice showed decreased numbers of Ly6Chigh monocytes in infarcted hearts compared to wild-type mice (491 vs. 915 monocytes/mg infarct tissue, p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: