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December 7, 2012Thrombosis and Haemostasis

CXCR4 positive and angiogenic monocytes in myocardial infarction

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Population

90 patients, comprising 50 with ST-elevation myocardial infarction and 40 with stable coronary artery disease.

Design

Cohort

Follow-up

30 days for monocyte counts, 6 weeks for ejection fraction

Authors

BWBenjamin WrigleySMSilvia Montoro‐GarcíaGLGregory Y.H. Lip

Discussion

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Overview

Mon2 monocyte dynamics were associated with LVEF recovery after STEMI; leaves open whether targeting CXCR4+ subsets improves remodeling.

Structured PICO

P
Population
90 patients, comprising 50 with ST-elevation myocardial infarction (STEMI) and 40 with stable coronary artery disease (CAD).
C
Comparator
Patients with stable coronary artery disease (n=40)
O
Outcome
Dynamic alterations of reparative CXCR4+ monocytes, and CD34+ and KDR+ monocytes with angiogenic potential measured on days 1, 3, 7 and 30 post-MIsurrogate

The intermediate monocyte subset (Mon2) plays a prominent role in post-MI reparative processes, and its dynamic changes correlate with inflammatory markers and subsequent left ventricular ejection fraction.

Cite This Study

Wrigley et al. (2012) studied this question.

synapsesocial.com/papers/6a723937ac440176ef2a92a3https://doi.org/10.1160/th12-06-0395
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Also Consider

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