Does a favorable lifestyle reduce the risk of coronary artery disease in participants at high genetic risk?
Adherence to a healthy lifestyle is associated with a substantially reduced risk of coronary artery disease, even among individuals with a high genetic risk.
Across four studies involving 55,685 participants, genetic and lifestyle factors were independently associated with susceptibility to coronary artery disease. Among participants at high genetic risk, a favorable lifestyle was associated with a nearly 50% lower relative risk of coronary artery disease than was an unfavorable lifestyle. (Funded by the National Institutes of Health and others.).
Khera et al. (Sun,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: