What question did this study set out to answer?

To investigate the role of ING1 in stabilizing the p53 tumor suppressor by blocking polyubiquitination.

April 10, 2026Open Access

Expression of Concern: The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination

Key Points

To investigate the role of ING1 in stabilizing the p53 tumor suppressor by blocking polyubiquitination.
Assessment of p53 stabilization mechanisms
Analysis of protein interactions involving ING1
Examination of Cyclin D1 levels in various conditions
Identification of potential image issues in figures related to ING1 and p53
Concerns raised about the reliability of specific experimental data
Discontinuities noted in the representation of protein panels

Abstract

Expression of Concern: The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination The PLOS One Editors After this article 1 was published, concerns were raised regarding Figs 1 and S7.Specifically, In Fig 1C, there appear to be vertical discontinuities between the ING1a and + LC lanes of the Cyclin D1 and Ub panels. In Fig 1D, the ING1b + P53 and ING1b lanes of the Cyclin D1 panel appear to be discontinuous with the adjacent background.

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