What question did this study set out to answer?

To evaluate the efficacy and safety of sildenafil in preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).

April 10, 2026

Sildenafil for bronchopulmonary dysplasia‐associated pulmonary hypertension: A systematic search and narrative synthesis

Key Points

To evaluate the efficacy and safety of sildenafil in preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
Conducted a systematic search for relevant studies
Focused on sildenafil treatment in preterm infants
Narrative synthesis of available evidence
Insufficient evidence supports sildenafil's effect on mortality and morbidity in BPD-PH infants
Calls for more research, especially randomized controlled trials

Abstract

Evidence to support the use of sildenafil treatment for preterm infants with BPD-PH to improve mortality and morbidity is lacking. More research, particularly randomized controlled trials, on the efficacy and safety of sildenafil treatment for preterm BPD-PH infants is needed.

Sildenafil for bronchopulmonary dysplasia‐associated pulmonary hypertension: A systematic search and narrative synthesis

Key Points

Abstract

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