Does cardiac-specific overexpression of GLUT1 prevent contractile dysfunction and LV dilation in mice with chronic pressure overload?
Cardiac-specific overexpression of GLUT1 protects against heart failure development in a mouse model of chronic pressure overload.
We found that increasing insulin-independent glucose uptake and glycolysis in adult hearts does not compromise cardiac function. Furthermore, we demonstrate that increasing glucose utilization in hypertrophied hearts protects against contractile dysfunction and LV dilation after chronic pressure overload.
Liao et al. (Tue,) studied this question.