Key result
GLUT1 overexpression prevents contractile dysfunction and LV dilation after pressure overload in mice.
Why the study?
The effects of increasing insulin-independent glucose uptake and glycolysis on cardiac function and protection against heart failure due to pressure overload were unclear.
Does cardiac-specific overexpression of GLUT1 prevent contractile dysfunction and LV dilation in mice with chronic pressure overload?
Does cardiac-specific overexpression of GLUT1 prevent contractile dysfunction and LV dilation in mice with chronic pressure overload?
Cardiac-specific overexpression of GLUT1 protects against heart failure development in a mouse model of chronic pressure overload.
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Animal data suggest metabolic targets in hypertrophy merit human investigation; should not change clinical practice.
Liao et al. (2002) studied this question. Cardiac-specific overexpression of GLUT1 increases glucose utilization, protecting against contractile dysfunction and LV dilation after chronic pressure overload in mice.
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