Why the study?
Does essential hypertension alter insulin-stimulated glucose uptake in the heart and skeletal muscle compared to normotensive controls?
Population
24 subjects, including 10 with mild essential hypertension and 14 normal normotensive subjects.
Comparison
Euglycemic insulin clamp and positron emission… vs Normotensive healthy control subjects.
Design
Case-control
Authors
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May signal early cardiac metabolic shifts in hypertension; hypothesis-generating for pre-LVH changes and requires prospective validation.
Does essential hypertension alter insulin-stimulated glucose uptake in the heart and skeletal muscle compared to normotensive controls?
In mild essential hypertension, insulin-stimulated glucose uptake is decreased in skeletal muscle but increased in the heart, potentially reflecting increased cardiac work prior to the development of left ventricular hypertrophy.
Nuutila et al. (1995) studied this question.
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