Key result
Patients with coronary heart disease exhibited a 46% reduction in myocardial glucose uptake compared to healthy controls, demonstrating flow-independent cardiac insulin resistance.
Why the study?
Do patients with coronary artery disease and regional wall motion abnormalities exhibit impaired myocardial and skeletal muscle glucose uptake independent of blood flow compared to healthy controls?
Population
15 male patients with angiographically proven coronary artery disease and chronic regional wall motion…
Comparison
Measurement of regional glucose uptake and blood… vs Age- and weight-matched healthy subjects.
Design
Case-control
Authors
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Cardiac insulin resistance may occur in CHD independent of flow; hypothesis-generating and leaves open whether metabolic therapies alter outcomes.
Case-Control (n=21)
No
Do patients with coronary artery disease and regional wall motion abnormalities exhibit impaired myocardial and skeletal muscle glucose uptake independent of blood flow compared to healthy controls?
Absolute Event Rate: 0.38% vs 0.7%
p-value: p=0.0005
Patients with coronary artery disease and low ejection fraction exhibit both myocardial and skeletal muscle insulin resistance that is independent of regional blood flow.
Paternostro et al. (1996) conducted a case-control in Coronary Heart Disease (n=21). Euglycemic hyperinsulinemia (insulin clamp) vs. Healthy age- and weight-matched subjects was evaluated on Myocardial glucose uptake (μmol/min/g) (p=0.0005). Patients with coronary heart disease exhibited a 46% reduction in myocardial glucose uptake compared to healthy controls, demonstrating flow-independent cardiac insulin resistance.
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