Key result
Targeted inactivation of Galpha(i2) or Galpha(i3) in mice did not alter basal cardiac function or sensitivity to beta-adrenergic stimulation compared to wild-type mice.
Why the study?
Does targeted inactivation of Galpha(i2) or Galpha(i3) alter basal cardiac function or sensitivity to beta-adrenergic stimulation in nonpathological myocardium?
Does targeted inactivation of Galpha(i2) or Galpha(i3) alter basal cardiac function or sensitivity to beta-adrenergic stimulation in nonpathological myocardium?
Inhibitory G proteins Galpha(i2) and Galpha(i3) do not play an observable role in mediating basal cardiac function or sensitivity to beta-adrenergic stimulation in nonpathological myocardium.
Authors
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Gαi2/3 inactivation shows no effect on basal mouse cardiac function; leaves open roles in disease models.
Jain et al. (2001) studied Nonpathological myocardium. Targeted inactivation of Galpha(i2) or Galpha(i3) vs. Wild-type mice was evaluated on In vivo cardiac function and ex vivo cardiac response to inotropic stimulation. Targeted inactivation of Galpha(i2) or Galpha(i3) in mice did not alter basal cardiac function or sensitivity to beta-adrenergic stimulation compared to wild-type mice.
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