Why the study?
Does insulin stimulation alter glucose uptake and GLUT-4 mRNA content in the hearts of spontaneously hypertensive rats compared to normotensive controls?
Does insulin stimulation alter glucose uptake and GLUT-4 mRNA content in the hearts of spontaneously hypertensive rats compared to normotensive controls?
The hypertrophied heart of the spontaneously hypertensive rat exhibits insulin resistance, potentially driven by decreased GLUT-4 mRNA content.
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Hypothesis-generating for cardiac insulin resistance in hypertension; human studies needed to assess relevance.
Paternostro et al. (1995) studied this question.
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