What question did this study set out to answer?

To determine whether spontaneous hypertension in young rats is accompanied by peripheral insulin resistance or impaired hepatic glucose output.

January 1, 1992AJP Endocrinology and Metabolism

Hypertension without peripheral insulin resistance in spontaneously hypertensive rats

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Authors

TBThomas A. BuchananGeneral / Preventive / Lipids GSGeorge F SiposUniversity of Southern California NMNelson G MadrilejoUniversity of Southern California

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Implication

Comparative animal study demonstrates normal insulin sensitivity despite high blood pressure in spontaneously hypertensive rats, suggesting peripheral insulin resistance does not initiate...

Key Points

To determine whether spontaneous hypertension in young rats is accompanied by peripheral insulin resistance or impaired hepatic glucose output.
Conducted euglycemic clamp experiments using labeled glucose in conscious, mobile spontaneously hypertensive rats (SHR, N=8) and normotensive Wistar-Kyoto rats (WKY, N=11) aged 9–10 weeks.
Infused somatostatin combined with graded doses of human insulin to measure hepatic glucose output and peripheral glucose clearance under both basal and physiological hyperinsulinemic conditions.
Systolic blood pressure was significantly elevated in SHR compared to WKY rats (P < 0.001).
Fasting plasma insulin (P > 0.4), glucose (P > 0.07), basal hepatic glucose output (P > 0.25), and basal glucose clearance (P > 0.2) showed no significant differences between SHR and WKY groups.
During hyperinsulinemic clamps, insulin sensitivity based on increased glucose clearance (P > 0.3) did not differ significantly between groups, and hepatic glucose output was fully suppressed in both.

Cite This Study

Buchanan et al. (1992) studied this question.

synapsesocial.com/papers/6a83513af5f8b1becfae33cb https://doi.org/10.1152/ajpendo.1992.262.1.e14

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Implication

Comparative animal study demonstrates normal insulin sensitivity despite high blood pressure in spontaneously hypertensive rats, suggesting peripheral insulin resistance does not initiate...

Hypertension without peripheral insulin resistance in spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Hypertension without peripheral insulin resistance in spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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