Why the study?
Does insulin affect norepinephrine overflow differently in salt-loaded spontaneously hypertensive rats compared to normotensive controls?
Population
Young spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY)
Comparison
Salt loading and insulin exposure to isolated… vs Low salt diet and WKY controls
Design
Preclinical
Follow-up
4 weeks (for salt loading)
Authors
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May implicate sympathetic insulin hyporeactivity in salt-induced SHR hypertension; hypothesis-generating and leaves open human relevance.
Does insulin affect norepinephrine overflow differently in salt-loaded spontaneously hypertensive rats compared to normotensive controls?
Hyporeactivity to insulin at peripheral sympathetic nerves may contribute to the development of salt-induced hypertension in young spontaneously hypertensive rats.
Shimosawa et al. (1996) studied this question.
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