Key result
Low-concentration insulin decreased norepinephrine reactivity in subcutaneous small resistance arteries of normotensive subjects, but this effect was lost in patients with hypertension and/or NIDDM.
Why the study?
Does insulin alter the contractile response to norepinephrine and acetylcholine in subcutaneous small resistance arteries of hypertensive and diabetic patients?
Population
39 subjects providing subcutaneous small resistance arteries
Comparison
Preincubation with insulin at low and high… vs Absence of insulin
Design
Preclinical
Authors
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May indicate vascular insulin resistance in hypertension/diabetes; leaves open its role in human disease progression.
Does insulin alter the contractile response to norepinephrine and acetylcholine in subcutaneous small resistance arteries of hypertensive and diabetic patients?
p-value: p=0.02 to 0.05
Physiological concentrations of insulin decrease vascular reactivity to norepinephrine in healthy subjects, but this vasodilatory effect is lost in patients with hypertension and/or type 2 diabetes.
Ciuceis et al. (2008) studied Essential hypertension and non-insulin-dependent diabetes mellitus (n=39). Insulin vs. Absence of insulin was evaluated on Contractile response to norepinephrine (p=0.02 to 0.05). Low-concentration insulin decreased norepinephrine reactivity in subcutaneous small resistance arteries of normotensive subjects, but this effect was lost in patients with hypertension and/or NIDDM.
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