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December 1, 1994American Journal of Hypertension

Effect of Insulin on the Venoconstrictive Response to Norepinephrine in Normal Human Subjects: The Influence of Sodium Status

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Why the study?

Does sodium status influence the local vasodilatory action of insulin on a dorsal hand vein in healthy human subjects?

Population

14 healthy human subjects

Comparison

Low sodium diet for 7 days followed by local… vs High sodium diet for 7 days followed by local…

Design

Other

Follow-up

7 days per diet phase

Authors

FWFlorence WongUniversity Health NetworkJMJudith MillerUniversity of New EnglandLBLaurence M. BlendisBoston University

Discussion

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Implication

High sodium intake may blunt local insulin venodilation; hypothesis-generating for sodium restriction in hypertension.

Structured PICO

Does sodium status influence the local vasodilatory action of insulin on a dorsal hand vein in healthy human subjects?

P
Population
14 healthy human subjects
I
Intervention
Low sodium diet (20 mmol) for 7 days followed by local insulin administration
C
Comparator
High sodium diet (200 mmol) for 7 days followed by local insulin administration
O
Outcome
Local vasodilatory action of insulin on a dorsal hand vein preconstricted with norepinephrinesurrogate

A high sodium diet reduces tissue sensitivity to insulin and impairs its vasodilatory response, suggesting that sodium restriction may have beneficial effects on the control of essential hypertension.

Cite This Study

Wong et al. (1994) studied this question.

synapsesocial.com/papers/6a996ed896b2e868bfe11e03https://doi.org/10.1093/ajh/7.12.1097
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin Attenuates Norepinephrine- Induced Venoconstriction1995 · 88 citations
  2. 2Effects of Insulin on Endothelial and Contractile Function of Subcutaneous Small Resistance Arteries of Hypertensive and Diabetic Patients2008 · 9 citations
  3. 3Dietary salt restriction increases vascular insulin resistance*1996 · 37 citations
  4. 4Fatty Acids, Not Insulin, Modulate α1-Adrenergic Reactivity in Dorsal Hand Veins1997 · 12 citations
  5. 5Insulin-Mediated Venodilation Is Impaired in Patients With High Cholesterol1998 · 12 citations