Key result
Insulin caused highly reproducible dose-dependent increases in mean venous diameter when combined with norepinephrine compared with norepinephrine alone (P<.001).
Why the study?
Does insulin attenuate norepinephrine-induced venoconstriction in healthy subjects?
Population
16 healthy men and women (10 in the primary dose-response study, 6 in the methylene blue substudy)
Comparison
Insulin infusion combined with norepinephrine… vs Norepinephrine alone (100 ng/min)
Design
Other
Follow-up
5-minute observation periods per dose
Authors
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May enable quantitative venomotor assessment; leaves open clinical utility in hypertension pending validation.
Does insulin attenuate norepinephrine-induced venoconstriction in healthy subjects?
p-value: p=<.001
Insulin attenuates norepinephrine-induced venoconstriction in vivo through a mechanism that is likely cyclic guanylate monophosphate dependent.
Grover et al. (1995) studied Healthy (n=16). Insulin vs. Norepinephrine alone was evaluated on Mean venous diameter (p=<.001). Insulin caused highly reproducible dose-dependent increases in mean venous diameter when combined with norepinephrine compared with norepinephrine alone (P<.001).
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