Key result
Insulin significantly attenuated noradrenaline-induced vasoconstriction in resistance arteries (13.1% reduction in maximum tension; P<0.01), an effect dependent on nitric oxide release.
Population
Mesenteric resistance arteries from 10-week-old male Wistar rats
Comparison
Exposure to physiological concentrations of… vs No insulin
Design
Preclinical
Authors
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Suggests insulin modulates vascular tone via NO in preclinical models; leaves open relevance to human hypertension or diabetic vasculopathy.
p-value: p=< 0.01
Insulin attenuates noradrenaline-induced vasoconstriction in resistance arteries via nitric oxide release, which may be relevant to the pathogenesis of hypertension and diabetic microvascular disease.
Walker et al. (1997) studied this question. Insulin vs. no insulin was evaluated on reduction in maximum tension at 3 x 10(-5) mol/l noradrenaline (p=< 0.01). Insulin significantly attenuated noradrenaline-induced vasoconstriction in resistance arteries (13.1% reduction in maximum tension; P<0.01), an effect dependent on nitric oxide release.
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