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November 1, 1997Hypertension

Insulin Enhances Endothelial α2-Adrenergic Vasorelaxation by a Pertussis Toxin Mechanism

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Why the study?

Does insulin enhance endothelial alpha2-adrenergic vasorelaxation in rat aortic models?

Population

Aortic rings and primary cultured aortic endothelial cells from Wistar-Kyoto rats and spontaneously…

Comparison

Insulin exposure for 30 minutes vs Control conditions (no insulin exposure)

Design

Preclinical

Authors

GLGiuseppe LemboGeneral CardiologyGIGuido IaccarinoHeart Failure & TransplantCVCarmine VecchioneGeneral Cardiology

Discussion

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Implication

Caution against extrapolating rat aortic findings to patients; leaves open whether insulin-alpha2 interactions contribute to human hypertension.

Structured PICO

Does insulin enhance endothelial alpha2-adrenergic vasorelaxation in rat aortic models?

P
Population
Aortic rings and primary cultured aortic endothelial cells from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats
I
Intervention
Insulin exposure (30, 100, and 500 microU/mL) for 30 minutes
C
Comparator
Control conditions (no insulin exposure)
O
Outcome
Endothelium-dependent relaxations generated by acetylcholine, adenosine diphosphate, UK 14,304, and ionomycin, and conversion of [3H]arginine to [3H]citrullinesurrogate

Insulin selectively enhances alpha2-adrenergic endothelial vasorelaxation via a pertussis toxin-sensitive mechanism involving nitric oxide production, a pathway that is impaired in spontaneously hypertensive rats.

Cite This Study

Lembo et al. (1997) studied this question.

synapsesocial.com/papers/6a72c80784cc45bb7be02c4dhttps://doi.org/10.1161/01.hyp.30.5.1128
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes.1988 · 107 citations
  2. 2Human insulin-mediated enhancement of vascular beta-adrenergic responsiveness.1994 · 38 citations
  3. 3Insulin Attenuates Norepinephrine- Induced Venoconstriction1995 · 88 citations
  4. 4Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans.1993 · 55 citations
  5. 5Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.1991 · 1,085 citations