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July 1, 1977Diabetes

The Effect of Insulin on Vascular Reactivity to Norepinephrine

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Why the study?

Does insulin reduce the vasoconstrictor response to norepinephrine in the isolated perfused rat tail?

Population

Isolated perfused rat tail (resistance bed)

Design

Preclinical

Authors

WAWilliam AlexanderSt Thomas' HospitalROR. J. OakeLeeds General Infirmary

Discussion

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Implication

May support insulin's vasodilatory role in diabetes; hypothesis-generating for human blood pressure effects.

Structured PICO

Does insulin reduce the vasoconstrictor response to norepinephrine in the isolated perfused rat tail?

P
Population
Isolated perfused rat tail (resistance bed)
I
Intervention
Insulin (concentrations of 120 mU./ml. and 150 micronU./ml.)
O
Outcome
Vasoconstrictor response to norepinephrinesurrogate

Insulin significantly attenuates the vasoconstrictor response to norepinephrine in isolated rat tails, providing a potential mechanism for its hypotensive action in diabetics.

Cite This Study

Alexander et al. (1977) studied this question.

synapsesocial.com/papers/6a899f40b1e5d05ea8ec7b68https://doi.org/10.2337/diab.26.7.611
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin-Induced Attenuation of Noradrenaline-Mediated Vasoconstriction in Resistance Arteries from Wistar Rats is Nitric Oxide Dependent1997 · 20 citations
  2. 2Effects of Insulin on Vasoconstrictive Responses to Norepinephrine and Angiotensin II in Rabbit Femoral Artery and Vein1988 · 103 citations
  3. 3Insulin-Induced Biphasic Responses in Rat Mesenteric Vascular Bed2001 · 33 citations
  4. 4Effects of Insulin on Endothelial and Contractile Function of Subcutaneous Small Resistance Arteries of Hypertensive and Diabetic Patients2008 · 9 citations
  5. 5Endothelin Antagonism Uncovers Insulin-Mediated Vasorelaxation In Vitro and In Vivo2001 · 54 citations