Key result
Combination therapy with trimetazidine and metoprolol improved exercise stress test results and angina symptoms compared to metoprolol alone in stable angina patients.
Why the study?
Does trimetazidine added to metoprolol improve exercise stress tests and angina symptoms in patients with stable effort angina?
Does trimetazidine added to metoprolol improve exercise stress tests and angina symptoms in patients with stable effort angina?
Adding trimetazidine to metoprolol improves exercise capacity and angina symptoms in patients with stable angina not fully controlled by beta-blocker monotherapy.
Supports trimetazidine addition to metoprolol for better angina control; extends prior evidence on metabolic-beta-blocker combinations.
Therapy with trimetazidine plus metoprolol produced significant improvements in exercise stress tests and the symptoms of angina relative to metoprolol alone. With its metabolic effect, devoid of any haemodynamic action, trimetazidine is useful for combination therapy in patients with stable angina insufficiently controlled by monotherapy with a beta-blocker.
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Hanna Szwed (2001) studied this question. Combination therapy with trimetazidine and metoprolol improved exercise stress test results and angina symptoms compared to metoprolol alone in stable angina patients.
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