Why the study?
Does trimetazidine added to diltiazem improve exercise time to 1 mm ST segment depression in male patients with stable angina uncontrolled on diltiazem alone?
Population
64 male patients with stable angina, uncontrolled on diltiazem alone
Comparison
Trimetazidine 60 mg daily added to diltiazem 180… vs Matching placebo daily added to diltiazem 180 mg…
Design
RCT, randomised, Double blind, placebo controlled
Follow-up
four weeks
Authors
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Supports trimetazidine addition to diltiazem in stable angina; extends evidence for metabolic agents as adjunctive therapy.
Does trimetazidine added to diltiazem improve exercise time to 1 mm ST segment depression in male patients with stable angina uncontrolled on diltiazem alone?
Adding trimetazidine to diltiazem significantly improves exercise tolerance and reduces anginal attacks in men with stable angina uncontrolled on diltiazem alone.
Manchanda et al. (1997) studied this question.
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