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July 1, 1982CirculationOpen Access

Increased exercise tolerance and reduced electrocardiographic ischemia with diltiazem in patients with stable angina pectoris.

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Why the study?

Does a single oral dose of diltiazem improve exercise tolerance and reduce electrocardiographic ischemia in men with chronic stable angina pectoris?

Population

12 men with chronic stable angina pectoris

Comparison

Diltiazem 120 mg single oral dose vs Placebo

Design

Other, double-blind

Follow-up

3 hours

Authors

PWP WagniartMontreal Neurological Institute and HospitalRFR. James FergusonMitre (United States)BCBernard ChaitmanAmerican College of Cardiology

Discussion

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Implication

May support acute diltiazem use in stable angina; leaves open durability of benefit and event reduction.

Structured PICO

Does a single oral dose of diltiazem improve exercise tolerance and reduce electrocardiographic ischemia in men with chronic stable angina pectoris?

P
Population
12 men with chronic stable angina pectoris
I
Intervention
Diltiazem 120 mg single oral dose
C
Comparator
Placebo
O
Outcome
Exercise tolerance and electrocardiographic ischemia (including heart rate, systolic blood pressure, rate-pressure product, and ST-segment depression) during a maximal exercise test on a bicycle ergometer 3 hours after ingestionsurrogate

A single oral dose of diltiazem significantly improves exercise tolerance and reduces electrocardiographic signs of myocardial ischemia in men with chronic stable angina.

Cite This Study

Wagniart et al. (1982) studied this question.

synapsesocial.com/papers/6a70f3bbe71d69abee08f5cbhttps://doi.org/10.1161/01.cir.66.1.23
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antianginal efficiency of nifedipine with and without a beta‐blocker, studied with exercise test. A double‐blind, randomized subacute study1979 · 104 citations
  2. 2Provocative testing with ergonovine to evaluate the efficacy of treatment with calcium antagonists in variant angina.1979 · 100 citations
  3. 3STUDIES ON A NEW 1, 5-BENZOTHIAZEPINE DERIVATIVE (CRD-401)1973 · 37 citations