Why the study?
Does diltiazem or nitrendipine improve blood pressure and angina symptoms in patients with moderate systemic hypertension and stable angina pectoris?
Population
48 patients with moderate systemic hypertension and stable angina pectoris
Comparison
Diltiazem 240 mg/day or Nitrendipine 20 mg/day… vs Placebo
Design
RCT, randomized, crossover, placebo-controlled
Authors
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Either agent may be selected for BP and angina control in these patients; confirms CCB equivalence on primary endpoints.
Does diltiazem or nitrendipine improve blood pressure and angina symptoms in patients with moderate systemic hypertension and stable angina pectoris?
Both diltiazem and nitrendipine are equally effective in reducing blood pressure and anginal attacks in patients with hypertension and stable angina, though diltiazem provides greater reduction in rate-pressure product and left ventricular mass.
Andreyev et al. (1991) studied this question.
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