Key result
Nifedipine and diltiazem similarly reduced anginal attacks and improved exercise tolerance compared to placebo in patients with severe stable angina, but diltiazem caused nocturnal bradycardia.
Why the study?
Does nifedipine compared to diltiazem or placebo reduce myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers?
Population
20 patients with severe stable angina pectoris and multivessel coronary artery disease treated with nitrates…
Comparison
Nifedipine added to background therapy of… vs Diltiazem and placebo added to background…
Design
RCT, randomized, cross-over, double-blind
Follow-up
7-8 weeks
Authors
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Favors nifedipine over diltiazem as add-on in severe stable angina on nitrates and beta-blockers; confirms comparable efficacy with superior safety.
RCT (n=20)
Double-blind
Cross-over
Does nifedipine compared to diltiazem or placebo reduce myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers?
In patients with severe stable angina on nitrates and beta-blockers, adding nifedipine or diltiazem improves antianginal and antiischemic effects, but nifedipine may be safer due to nocturnal bradycardia associated with diltiazem.
Meluzín et al. (1992) conducted an RCT in Severe stable angina pectoris and multivessel coronary artery disease (n=20). Nifedipine and diltiazem vs. Placebo was evaluated on Daily number of anginal attacks, nitroglycerin consumption, and exercise duration. Nifedipine and diltiazem similarly reduced anginal attacks and improved exercise tolerance compared to placebo in patients with severe stable angina, but diltiazem caused nocturnal bradycardia.
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