Why the study?
Does nifedipine reduce angina episodes and improve exercise tolerance in patients with severe coronary artery disease and disabling angina already receiving beta-blocker therapy?
Population
9 patients with severe coronary artery disease and disabling angina receiving either regular metoprolol or…
Comparison
Nifedipine 10 mg three times per day added to… vs Placebo added to beta-blocker therapy
Design
RCT, randomized, double blind
Authors
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Supports adding nifedipine to beta-blockers for refractory angina; extends evidence for combination therapy in severe CAD.
Does nifedipine reduce angina episodes and improve exercise tolerance in patients with severe coronary artery disease and disabling angina already receiving beta-blocker therapy?
The addition of nifedipine to beta-blocker therapy significantly reduces angina frequency and improves objective measures of exercise tolerance in patients with severe coronary artery disease.
Jenkins et al. (1982) studied this question.
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