February 22, 1985JAMA
Nifedipine-lnduced Hypotension and Myocardial Ischemia in Refractory Angina Pectoris
Why the study?
Does nifedipine induce hypotension and myocardial ischemia in patients with refractory angina pectoris?
Population
10 patients with refractory angina pectoris who regularly reported angina within 20 to 30 minutes of…
Comparison
Nifedipine vs Baseline
Design
Case_series
Follow-up
Acute
Authors
Discussion
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Implication
Nifedipine may provoke ischemia in refractory angina on background therapy; leaves open generalizability beyond this case series.
Structured PICO
Does nifedipine induce hypotension and myocardial ischemia in patients with refractory angina pectoris?
P
Population
10 patients with refractory angina pectoris (7 receiving combined beta-blocker and nitrate therapy, and 3 receiving nitrate treatment alone) who regularly reported angina within 20 to 30 minutes of nifedipine ingestion.
I
Intervention
Nifedipine (mean dosage 92 mg/day; range 60 to 120 mg/day)
C
Comparator
Baseline (before usual nifedipine dose administration)
O
Outcome
Changes in blood pressure, heart rate, and ECG (myocardial ischemia)safety
Nifedipine may provoke paradoxical angina and myocardial ischemia in certain patients with refractory angina receiving concomitant beta-blocker and/or nitrate therapy.
Cite This Study
William E. Boden (1985) studied this question.