Why the study?
Does nifedipine provoke hypotension and myocardial ischemia in patients with refractory angina pectoris receiving background nitrate and/or β-blocker therapy?
Population
10 patients with refractory angina pectoris who regularly reported angina within 20 to 30 minutes of…
Comparison
Nifedipine vs Baseline
Design
Case_series
Follow-up
Acute observation (within 20 to 30 minutes of ingestion)
Authors
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Nifedipine may provoke ischemia via hypotension in refractory angina on background therapy; hypothesis-generating and should not change practice.
Does nifedipine provoke hypotension and myocardial ischemia in patients with refractory angina pectoris receiving background nitrate and/or β-blocker therapy?
Nifedipine can paradoxically provoke angina and myocardial ischemia in patients with refractory angina receiving concomitant β-blocker and nitrate therapy, driven by significant hypotensive effects.
W. E. Boden (1985) studied this question.