April 1, 1981Annals of Internal Medicine
Efficacy of Nifedipine in Rest Angina Refractory to Propranolol and Nitrates in Patients with Obstructive Coronary Artery Disease
Why the study?
Does oral nifedipine reduce rest angina in patients with obstructive coronary artery disease refractory to propranolol and nitrates?
Population
19 patients with recurrent rest angina refractory to propranolol and oral or topical nitrates given to…
Design
Case_series
Follow-up
mean 6.2 +/- 3.4 months (for long-term subgroup)
Authors
Discussion
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Implication
May support nifedipine in refractory rest angina; hypothesis-generating and requires randomized confirmation before practice change.
Structured PICO
Does oral nifedipine reduce rest angina in patients with obstructive coronary artery disease refractory to propranolol and nitrates?
P
Population
19 patients with recurrent rest angina refractory to propranolol and oral or topical nitrates given to tolerance, with obstructive coronary artery disease.
I
Intervention
Oral nifedipine, 30 to 120 mg daily, added to background therapy of propranolol and nitrates.
O
Outcome
Frequency of rest angina (abolished, decreased, or no effect).patient reported
Nifedipine is highly effective in abolishing or reducing rest angina in patients with obstructive coronary artery disease who are refractory to standard therapy with propranolol and nitrates.
Cite This Study
Jeffrey W. Moses (1981) studied this question.