Key result
Nifedipine was effective in relieving attacks of Prinzmetal's angina unresponsive to conventional therapy, though lower doses lost effectiveness approximately 4 hours after administration.
Why the study?
Does nifedipine relieve attacks in a patient with Prinzmetal's angina unresponsive to conventional therapy?
Case Report (n=1)
Does nifedipine relieve attacks in a patient with Prinzmetal's angina unresponsive to conventional therapy?
Nifedipine is effective in relieving Prinzmetal's angina attacks, but concurrent nitrate withdrawal may precipitate myocardial infarction.
Nifedipine relieves refractory Prinzmetal angina; extends calcium-channel blocker use while cautioning against abrupt nitrate withdrawal.
A case is described in which nifedipine, a new coronary vasodilator, was effective in relieving attacks of Prinzmetal's angina unresponsive to conventional therapy. The extreme frequency of the anginal attacks provided evidence that lower doses of nifedipine lost their effectiveness approximately 4 hours after administration. A month after initiation of nifedipine, nitrates were withdrawn since they had been ineffective in controlling the attacks. A myocardial infarction occurred immediately, presumably due to coronary spasm.
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Muller et al. (1978) conducted a case report in Prinzmetal's angina (n=1). Nifedipine vs. Conventional therapy was evaluated on Relief of anginal attacks. Nifedipine was effective in relieving attacks of Prinzmetal's angina unresponsive to conventional therapy, though lower doses lost effectiveness approximately 4 hours after administration.
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