April 15, 1982New England Journal of Medicine
Nifedipine in Unstable Angina
Why the study?
Does adding nifedipine to conventional treatment reduce the failure of medical treatment in patients with unstable angina?
Population
138 patients with unstable angina
Comparison
Nifedipine added to conventional treatment vs Placebo added to conventional treatment
Design
RCT, randomized, double-blind
Follow-up
4 months
Authors
Discussion
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Implication
Supports adding nifedipine to conventional therapy in unstable angina; strengthens evidence for calcium channel blockade in acute coronary syndromes.
Structured PICO
Does adding nifedipine to conventional treatment reduce the failure of medical treatment in patients with unstable angina?
P
Population
138 patients with unstable angina
I
Intervention
Nifedipine added to conventional treatment
C
Comparator
Placebo added to conventional treatment
O
Outcome
Failure of medical treatment (composite of sudden death, myocardial infarction, or bypass surgery within four months)composite
The addition of nifedipine to conventional therapy safely and effectively reduces the risk of sudden death, myocardial infarction, or need for bypass surgery in patients with unstable angina.
Cite This Study
Gerstenblith et al. (1982) studied this question.