April 1, 1984Circulation
Nifedipine therapy for patients with threatened and acute myocardial infarction: a randomized, double-blind, placebo-controlled comparison.
Why the study?
Does nifedipine prevent progression to infarction or limit infarct size in patients with threatened or acute myocardial infarction?
Population
171 patients with ischemic pain of >45 min duration
Comparison
Nifedipine 20 mg orally every 4 hr for 14 days… vs Placebo plus standard care
Design
RCT, randomly assigned, double-blind, placebo-controlled
Follow-up
6 months
Authors
Discussion
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Implication
Increases early mortality without benefit on infarct progression in threatened MI; challenges prior hypotheses favoring nifedipine.
Structured PICO
Does nifedipine prevent progression to infarction or limit infarct size in patients with threatened or acute myocardial infarction?
P
Population
171 patients with ischemic pain of >45 min duration (105 with threatened myocardial infarction and 66 with acute myocardial infarction)
I
Intervention
Nifedipine 20 mg orally every 4 hr for 14 days plus standard care
C
Comparator
Placebo plus standard care
O
Outcome
Incidence of progression to infarction (for threatened MI) and infarct size index (MB-CK method)hard clinical
Cite This Study
Muller et al. (1984) studied this question.