Why the study?
Does intravenous nifedipine infusion provide safe and stable pharmacokinetics in patients with acute myocardial infarction?
Population
12 patients with acute myocardial infarction, starting treatment within 6 hours of onset of pain.
Design
Case_series
Follow-up
24 hours
Authors
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Supports stable IV nifedipine pharmacokinetics in AMI without raising myocardial O2 demand; leaves open clinical role pending controlled trials.
Does intravenous nifedipine infusion provide safe and stable pharmacokinetics in patients with acute myocardial infarction?
Intravenous nifedipine infusion in acute myocardial infarction achieves steady plasma concentrations without increasing myocardial oxygen requirements, but its use via peripheral veins is limited by a high rate of thrombophlebitis.
Heagerty et al. (1987) studied this question.
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