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June 1, 1992Anesthesia & Analgesia

Intravenous Nifedipine to Treat Hypertension After Coronary Artery Revascularization Surgery. A Comparison With Sodium Nitroprusside

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Why the study?

Does intravenous nifedipine improve blood pressure control and prevent postoperative ischemia compared to sodium nitroprusside in patients with hypertension after coronary revascularization?

Population

49 patients with good left ventricular function who became hypertensive after elective coronary…

Comparison

Intravenous nifedipine vs Intravenous sodium nitroprusside (SNP)

Design

RCT, parallel, randomized, open-label

Follow-up

perioperative period

Authors

HNHoward J. NathanUniversity of OttawaSRSylvie Lagani reUniversity of OttawaLDLouise M. DubUniversity of Ottawa

Discussion

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Implication

Nifedipine matches SNP for post-revascularization hypertension control without ischemic advantage; confirms both as equivalent options in this population.

Structured PICO

Does intravenous nifedipine improve blood pressure control and prevent postoperative ischemia compared to sodium nitroprusside in patients with hypertension after coronary revascularization?

P
Population
49 patients with good left ventricular function who became hypertensive after elective coronary revascularization surgery (n=21 in nifedipine group, n=28 in SNP group).
I
Intervention
Intravenous nifedipine
C
Comparator
Intravenous sodium nitroprusside (SNP)
O
Outcome
Success rate of maintaining mean arterial pressure less than 90 mm Hg without requiring the addition of the alternative drug, and incidence of adverse ST-segment changes or perioperative myocardial infarction.surrogate

Intravenous nifedipine is safe and effective for controlling hypertension after coronary revascularization but offers no advantage over sodium nitroprusside in preventing postoperative ischemia or infarction.

Cite This Study

Nathan et al. (1992) studied this question.

synapsesocial.com/papers/6a769b38808ac7b5917d21c8https://doi.org/10.1213/00000539-199206000-00006

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nifedipine versus nitroprusside for controlling hypertensive episodes during coronary artery bypass surgery1984 · 24 citations
  2. 2Nifedipine infusion in acute myocardial infarction: Experience in twelve patients1987 · 5 citations
  3. 3A Comparison of Intravenous Nicardipine and Sodium Nitroprusside in the Immediate Treatment of Severe Hypertension1994 · 80 citations
  4. 4The Comparision of Nicardipine and Sodium Nitroprusside on Postoperative Hypertension after Coronary Artery Bypass Graft Surgery2002
  5. 5Nifedipine reduces the incidence of myocardial infarction and transient ischemia in patients undergoing coronary bypass grafting.1991 · 49 citations