Can unstable angina pectoris be due to increased coronary vasomotor tone?
Why the study?
Does nifedipine improve coronary vasodilation and relieve symptoms in patients with unstable angina pectoris?
Population
64 patients total: 12 with symptoms of coronary artery disease undergoing arteriography, and 52 with…
Comparison
Nifedipine. vs Baseline for the 12 patients; no comparator for…
Design
Case_series
Follow-up
Up to 24 hours
Authors
Discussion
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Member takes
Implication
May support nifedipine in refractory unstable angina; leaves open need for randomized confirmation.
Structured PICO
Does nifedipine improve coronary vasodilation and relieve symptoms in patients with unstable angina pectoris?
P
Population
64 patients total: 12 with symptoms of coronary artery disease undergoing arteriography, and 52 with impending myocardial infarction refractory to maximal beta-adrenergic blockade, nitrates, and bedrest.
I
Intervention
Nifedipine (0.15 mg intracoronary for the 12 patients; 60 mg orally for 24 hours for the 52 patients).
C
Comparator
Baseline (prior to drug administration) for the 12 patients; no comparator for the 52 patients.
O
Outcome
Mean diameter of normal, stenotic and poststenotic coronary segments (in 12 patients) and symptom relief (in 52 patients).surrogate
Nifedipine effectively relieves symptoms in patients with unstable angina refractory to beta-blockers and nitrates, likely by reducing coronary vasomotor tone.
Cite This Study
Serruys et al. (1980) studied this question.