January 1, 1983Catheterization and Cardiovascular Diagnosis
Salutary effect of nifedipine in pacing‐induced angina: Relation to afterload reduction
Why the study?
Does nifedipine improve pacing-induced angina threshold in patients with fixed obstructive coronary artery disease?
Population
20 patients with fixed obstructive coronary artery disease undergoing diagnostic cardiac catheterization
Comparison
Nifedipine 20 mg sublingually vs Baseline (before nifedipine administration)
Design
Cohort
Follow-up
30 minutes after administration
Authors
Discussion
Loading...
Member takes
Implication
Nifedipine was associated with higher paced HR at angina onset via lower afterload; supports mechanistic insight in fixed CAD but leaves clinical adoption open.
Structured PICO
Does nifedipine improve pacing-induced angina threshold in patients with fixed obstructive coronary artery disease?
P
Population
20 patients with fixed obstructive coronary artery disease undergoing diagnostic cardiac catheterization
I
Intervention
Nifedipine 20 mg sublingually
C
Comparator
Baseline (before nifedipine administration)
O
Outcome
Hemodynamic parameters at the onset of pacing-induced angina (heart rate, systolic arterial pressure, double product, pulmonary arterial occlusive pressure)surrogate
Nifedipine exerts its antianginal effect in pacing-induced angina by reducing left ventricular afterload and decreasing myocardial oxygen demand, rather than increasing the rate-pressure product threshold for ischemic pain.
Cite This Study
Tiefenbrunn et al. (1983) studied this question.