Key result
Trimetazidine had similar efficacy to propranolol in men with stable angina, with no significant difference in anginal attack rate per week (MD 2; 95% CI -4.4 to 0.5).
Why the study?
Does trimetazidine provide similar anti-anginal efficacy compared to propranolol in men with stable angina?
Population
149 men with stable angina and > 1 mm ST-depression on exercise test
Comparison
Trimetazidine 20 mg three times daily vs Propranolol 40 mg three times daily
Design
RCT, double-blind
Follow-up
3 months
Authors
Loading...
Trimetazidine offers a heart rate-neutral alternative to propranolol in stable angina; confirms comparable efficacy in this RCT.
RCT (n=149)
Double-blind
parallel group
Yes
Does trimetazidine provide similar anti-anginal efficacy compared to propranolol in men with stable angina?
Mean Difference: 2 (95% CI -4.4–0.5)
Trimetazidine 20 mg three times daily demonstrated similar anti-anginal efficacy to propranolol 40 mg three times daily in men with stable angina over 3 months.
Detry et al. (1994) conducted an RCT in stable angina (n=149). Trimetazidine vs. propranolol (40 mg three times daily) was evaluated on anginal attack rate per week (MD 2, 95% CI -4.4, 0.5). Trimetazidine had similar efficacy to propranolol in men with stable angina, with no significant difference in anginal attack rate per week (MD 2; 95% CI -4.4 to 0.5).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: