Key result
Addition of trimetazidine MR to metoprolol in patients with stable effort angina increased threshold exercise duration by 77.1±18.1 seconds in those where monotherapy was ineffective.
Why the study?
Does trimetazidine MR added to metoprolol improve exercise tolerance in patients with stable effort angina?
Observational (n=28)
Does trimetazidine MR added to metoprolol improve exercise tolerance in patients with stable effort angina?
Mean Difference: 77.1
The addition of trimetazidine MR to metoprolol enhances antianginal and anti-ischemic efficacy, particularly improving exercise duration in patients unresponsive to metoprolol monotherapy.
May support trimetazidine addition for exercise tolerance in metoprolol-refractory angina; hypothesis-generating pending randomized confirmation.
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Bardybakhin et al. (2013) conducted an observational in stable effort angina (n=28). trimetazidine MR vs. metoprolol monotherapy was evaluated on threshold exercise duration (77.1±18.1 s increase). Addition of trimetazidine MR to metoprolol in patients with stable effort angina increased threshold exercise duration by 77.1±18.1 seconds in those where monotherapy was ineffective.
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