January 8, 2022Open Access

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

SDShuohui DongKyung Hee University SLShuo LiangShandong University ZCZhiqiang ChengShenzhen Metro (China)

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Abstract

HIF-1α is a potential biomarker for 5-FU-resistant CRC, and targeting HIF-1a in combination with 5-FU may represent an effective therapeutic strategy in 5-FU-resistant CRC.

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