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January 8, 2022SHILAP Revista de lepidopterologíaOpen Access

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

Shuohui Dong Shuo Liang Zhiqiang Cheng Xiang Zhang Li Luo Linchuan Li Wenjie Zhang Songhan Li Qian Xu Mingwei Zhong Jiankang Zhu Guangyong Zhang Sanyuan Hu

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Abstract

HIF-1α is a potential biomarker for 5-FU-resistant CRC, and targeting HIF-1a in combination with 5-FU may represent an effective therapeutic strategy in 5-FU-resistant CRC.

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Cite This Study

Dong et al. (2022) studied this question.

synapsesocial.com/papers/69d96915da3af5b1d08367e5 https://doi.org/10.1186/s13046-021-02229-6

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