What question did this study set out to answer?

To investigate the relationship between the SOD2-rs4880 variant and the risk of age-related hearing loss (ARHL).

April 12, 2026

Association of a common SOD gene variant with ARHL risk: analysis by age, hearing threshold, and enzyme activity

AMAli MorabbiUniversity of Mazandaran HBHasti BalaliUniversity of Mazandaran AKAli Akbar KarimianKashan University of Medical Sciences

Key Points

To investigate the relationship between the SOD2-rs4880 variant and the risk of age-related hearing loss (ARHL).
Analyzed the SOD2 genetic variant in relation to hearing thresholds.
Examined the influence of aging on ARHL risk.
Investigated mitochondrial import mechanisms involving TOM20.
The SOD2-rs4880 variant is associated with increased risk of ARHL in older individuals.
Evidence suggests that the variant may disrupt mitochondrial import processes.

Abstract

The SOD2-rs4880 polymorphism may disrupt mitochondrial import via TOM20 and can be considered a molecular risk factor for ARHL, especially in older age.

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