Association of a common SOD gene variant with ARHL risk: analysis by age, hearing threshold, and enzyme activity

Key Points

• To investigate the relationship between the SOD2-rs4880 variant and the risk of age-related hearing loss (ARHL).
• Analyzed the SOD2 genetic variant in relation to hearing thresholds.
• Examined the influence of aging on ARHL risk.
• Investigated mitochondrial import mechanisms involving TOM20.
• The SOD2-rs4880 variant is associated with increased risk of ARHL in older individuals.
• Evidence suggests that the variant may disrupt mitochondrial import processes.