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April 10, 2026Personalized Medicine

Association of a common SOD gene variant with ARHL risk: analysis by age, hearing threshold, and enzyme activity

Ali Morabbi Hasti Balali Ali Akbar Karimian

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Key Points

To investigate the relationship between the SOD2-rs4880 variant and the risk of age-related hearing loss (ARHL).
Analyzed the SOD2 genetic variant in relation to hearing thresholds.
Examined the influence of aging on ARHL risk.
Investigated mitochondrial import mechanisms involving TOM20.
The SOD2-rs4880 variant is associated with increased risk of ARHL in older individuals.
Evidence suggests that the variant may disrupt mitochondrial import processes.

Implication

Analysis reveals a link between SOD2 gene variant and age-related hearing loss, suggesting a molecular risk factor.

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Cite This Study

Morabbi et al. (2026) studied this question.

synapsesocial.com/papers/69db37774fe01fead37c57a8 https://doi.org/10.1080/17410541.2026.2655104

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