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May 5, 2026Pediatric Blood & CancerOpen Access

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Emily J. Mason John P. Woodhouse Joanna S. Yi M. Monica Gramatges Olga A. Taylor Veronica A. Morales Shalini Dhamodharan M. Roberts Karen R. Rabin Philip J. Lupo Michael E. Scheurer Van Huynh Steven D. Mittelman Etan Orgel Austin Brown

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Key Points

To explore the relationship between SOD2 genetic variants and hepatotoxicity in pediatric leukemia across different ethnic groups.
Analyzed genetic data from children with Acute Lymphoblastic Leukemia
Compared hepatotoxicity rates between Hispanic and non-Hispanic children
Calculated adjusted odds ratios for hepatotoxicity linked to SOD2 rs4880 variant.
Hispanic children showed increased odds of hepatotoxicity (aOR = 1.81) associated with SOD2 rs4880 variant
Non-Hispanic children demonstrated decreased odds of hepatotoxicity (aOR = 0.55)
Evidence of genetic variations impacting hepatotoxic risk across ethnicities.

Implication

Research demonstrates ethnic differences in hepatotoxicity associated with SOD2 genetic variants in children, suggesting varied risk factors.

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Cite This Study

Mason et al. (2026) studied this question.

synapsesocial.com/papers/69fbe3aa164b5133a91a2ddd https://doi.org/10.1002/1545-5017.70387

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