Objective: To investigate the association of serum 25(OH)D levels with dengue severity in Vietnamese children and the association of common VDR gene polymorphisms with disease outcomes. Methods: This cross-sectional study included 178 children with confirmed dengue at a tertiary hospital in 2024. Serum 25(OH)D levels were measured, and 4 VDR polymorphisms (FokI, ApaI, TaqI, BsmI) were genotyped. Associations with WHO-defined severity were assessed using logistic regression. Results: Severe dengue was more common in older children and was characterized by greater plasma leakage and thrombocytopenia ( P .05). Conclusion: Our findings suggest vitamin D status may be more relevant to dengue severity than inherited VDR variation.
Phan et al. (Sun,) studied this question.