Cross-sectional study investigates vitamin D levels and VDR gene variations affecting dengue severity in children, suggesting vitamin D is significant.
Objective: To investigate the association of serum 25(OH)D levels with dengue severity in Vietnamese children and the association of common VDR gene polymorphisms with disease outcomes. Methods: This cross-sectional study included 178 children with confirmed dengue at a tertiary hospital in 2024. Serum 25(OH)D levels were measured, and 4 VDR polymorphisms (FokI, ApaI, TaqI, BsmI) were genotyped. Associations with WHO-defined severity were assessed using logistic regression. Results: Severe dengue was more common in older children and was characterized by greater plasma leakage and thrombocytopenia ( P < .001). Serum 25(OH)D concentrations were independently and inversely associated with dengue severity, with an adjusted odds ratio of 0.89 (95% CI: 0.85-0.93; P < .001). In contrast, allele and genotype distributions of the 4 VDR polymorphisms did not differ significantly across severity groups ( P > .05). Conclusion: Our findings suggest vitamin D status may be more relevant to dengue severity than inherited VDR variation.
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Phan et al. (2026) studied this question.
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