Pine pollen fiber alleviates constipation induced by loperamide in mice: Focus on gastrointestinal motility-related hormones, short-chain fatty acids, and gut microbiota changes

Key Points

• The study aims to explore the effects of pine pollen fiber on constipation induced by loperamide in mice and its influence on gut health.
• Administered loperamide to induce constipation in mice
• Supplemented with pine pollen fiber to assess its effects
• Measured gastrointestinal motility-related hormones
• Analyzed changes in short-chain fatty acids and gut microbiota
• Pine pollen fiber significantly improved gastrointestinal motility in loperamide-treated mice
• Increased levels of beneficial short-chain fatty acids were observed
• Alterations in gut microbiota composition were noted, favoring beneficial microbes