Pine pollen fiber alleviates constipation induced by loperamide in mice: Focus on gastrointestinal motility-related hormones, short-chain fatty acids, and gut microbiota changes

Zhiwei Li; Yong Cheng; Dandan Ma; Liduan Yin; Tong Wang; Zhaojun Wang; Qiuming Chen; Maomao Zeng; J. R. Chen; Benu Adhikari; Zongping Zheng; Zhiyong He

doi:10.1039/d6fo00700g

January 1, 2026Food & Function

Pine pollen fiber alleviates constipation induced by loperamide in mice: Focus on gastrointestinal motility-related hormones, short-chain fatty acids, and gut microbiota changes

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Key Points

The study aims to explore the effects of pine pollen fiber on constipation induced by loperamide in mice and its influence on gut health.
Administered loperamide to induce constipation in mice
Supplemented with pine pollen fiber to assess its effects
Measured gastrointestinal motility-related hormones
Analyzed changes in short-chain fatty acids and gut microbiota
Pine pollen fiber significantly improved gastrointestinal motility in loperamide-treated mice
Increased levels of beneficial short-chain fatty acids were observed
Alterations in gut microbiota composition were noted, favoring beneficial microbes

Implication

Investigates pine pollen fiber's effects on alleviating constipation in mice, highlighting its potential mechanisms.

Abstract

Constipation, a prevalent gastrointestinal disorder, urgently requires safe and effective intervention strategies. Natural dietary fibers have gained attention for their potential to alleviate constipation through multiple mechanisms. This study investigated...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69df2ae6e4eeef8a2a6afdde https://doi.org/10.1039/d6fo00700g

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Pine pollen fiber alleviates constipation induced by loperamide in mice: Focus on gastrointestinal motility-related hormones, short-chain fatty acids, and gut microbiota changes

Key Points

Implication

Abstract

Discussion

Cite This Study

Pine pollen fiber alleviates constipation induced by loperamide in mice: Focus on gastrointestinal motility-related hormones, short-chain fatty acids, and gut microbiota changes

Key Points

Implication

Abstract

Discussion

Cite This Study

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