Ferulic acid promotes proliferation and angiogenesis of cerebral microvascular endothelial cells in Moyamoya disease via the SIRT1/HIF-1α/VEGF-A axis

Key Points

• The aim is to investigate the effects of ferulic acid on endothelial cell proliferation and angiogenesis in the context of Moyamoya disease.
• Examined the impact of ferulic acid on Bend.3 cerebral microvascular endothelial cells.
• Evaluated oxidative stress and mitochondrial injury under conditions of oxygen-glucose deprivation (OGD).
• Analyzed the activation of the SIRT1/HIF-1α/VEGF-A signaling pathway.
• Ferulic acid reduced oxidative and mitochondrial damage in endothelial cells under OGD conditions.
• Promoted angiogenesis-related responses in Bend.3 cells through the activation of the SIRT1/HIF-1α/VEGF-A axis.