Photocatalytic synthesis of (hetero)biaryls via palladium-catalyzed hybrid-radical cross-coupling of (hetero)aryl halides and C-H functionalization of heteroarenes

Key Points

• The research aims to develop a palladium-catalyzed method for synthesizing (hetero)biaryls using light to activate the catalyst.
• Utilized light-activated palladium catalysts
• Conducted radical C–H (hetero)arylation of heterocycles
• Employed simple (hetero)aryl halides without external photocatalysts
• Explored mild reaction conditions with broad functional-group tolerance
• Achieved high site selectivity in bi(hetero)aryl formations
• Expanded the applicability of photoactivated palladium catalysis
• Demonstrated sustainability in C–C bond formation