Photocatalytic synthesis of (hetero)biaryls via palladium-catalyzed hybrid-radical cross-coupling of (hetero)aryl halides and C-H functionalization of heteroarenes

Light activates palladium catalysts to enable radical C–H (hetero)arylation of heterocycles using simple (hetero)aryl halides. Without the need of an external photocatalyst, the reaction proceeds under mild conditions with broad functional-group tolerance and high site selectivity, expanding photoactivated palladium catalysis for sustainable C–C bond formation in complex bi(hetero)aryl scaffolds.