The research aims to investigate the role of EWSR1::ATF1 in tumor development in salivary glands.
Utilized transgenic mice with salivary gland-specific EWSR1::ATF1 expression.
Monitored the development of tumors in major salivary glands.
Salivary gland-specific EWSR1::ATF1 expression resulted in malignant tumor formation.
Tumor incidence correlated with the expression pattern of the transgene.
Abstract
These results suggest that salivary gland-specific expression of EWSR1::ATF1 plays an important role in malignant tumor formation in major salivary glands.